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KMID : 0351619670080020297
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Kyungpook Medical Journal
1967 Volume.8 No. 2 p.297 ~ p.303
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Disappearance of Homologous and Heterologous Serum Albumin from Circulating Blood and the Effect of Cortisone
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Abstract
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Disappearance curves of intravenously injected I131-labelled homologous serum albumin and heterologous serum albumins in rabbits werecompared, and the distribution of I131-labelled he~terologous serum albumin in various tissues was studied.
The influence of cortisone on its disappearance were also observed.
In comparison with homologous albumin, the disappearance of heterologous serum albumin showed no significant difference in the early stage, but it began to increase with time. Especially noteworthy was that I131-bovine serum abumin disappeared from blood more raplidly than I13´-human serum albumin.
When heterologous serum albumin disappeared almost completely from peripheral blood, the distribution of it in various tissues was highest in kidney and followed by the kidney were the liver, lung and spleen in the decreaseing order. It was scarcely or not found in muscle and brain tissues.
In the group injected with cortisone acetate intramuscularly, 8mg/kg daily started one week prier to the experiment, the disappearance of homologous and heterologous serum albumins showed no difference from that of the control group. When daily 16 mg/kg was injected, hoR~ever, the disappearnce of heterologus albumin slovved dovvn a little without affecting homologous albumin. The distribution of heterologous albumin in various tissues was not affected by the cortisone treatment.
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